Cohort information

GERMANY				WP5
Organization		LMU University Hospital, LMU Munich
Name of cohort		KoCoImpf
Referring partner		LMU MUENCHEN
Cohort Information	Country(-ies), cities, regions or centers involved	Munich, Germany
	Time of data collection	06/2021	07/2022
	Enrolment	Inactive
	Study setting	Single center
Population	Age	Adults,Elderly
	Type	Prospective
	Total number of patients	6467
Data collection	Clinical data	True
	Serological data	True
	Genetic data	False
	Sample collection	True
	Sample collected	Whole blood	No
		PBMC	No
		Dry-spot blood	Yes
		Plasma	No
		Serum	No
		Stool	No
		NP swabs	No
		Other	None
Description	The aim of this study is to understand the short-, medium- and long-term immune response in individuals vaccinated against SARS-CoV-2. For this purpose, the infection and immune status (SARS-CoV-2-specific antibodies) of up to 6,500 individuals in the Munich area was determined at different time intervals over several months. For the first round of the study (June 2021 - December 2021), potential study participants from the Munich population were informed about the study at the Impfzentrum Riem, as well as in hospitals, medical and nursing facilities in Munich. Individuals who met the inclusion criteria were offered to test their antibody response against SARS-CoV-2 after COVID-19 vaccination. After detailed information and informed consent of the study participants, the study team performed a finger prick to collect capillary blood on the day of the first vaccination or at study recruitment. In addition, essential information such as SARS-CoV-2-specific vaccination and infection status, as well as other possible risk factors were queried in a questionnaire. For the follow-up study round (May 2022 - July 2022), capillary blood sampling was repeated. For this purpose, packages for blood collection from the fingertip were sent home to the study participants. Each blood collection testkit was accompanied by easy-to-understand instructions for blood collection from the fingertip, a questionnaire, and an individual cover letter. The blood samples and questionnaires were sent back to the Institute of Infectious Diseases and Tropical Medicine. HCWs of the LMU Medical Center underwent in-person visits in May 2022 and capillary blood samples were obtained on-site by trained personnel.
Publications	- Determinants of Anti-S Immune Response at 6 Months after COVID-19 Vaccination in a Multicentric European Cohort of Healthcare Workers – ORCHESTRA project [Frontiers in Immunology] - Determinants of Anti-S Immune Response at 9 Months after COVID-19 Vaccination in a Multicentric European Cohort of Healthcare Workers-ORCHESTRA Project [Viruses] - The Prospective COVID-19 Post-Immunization Serological Cohort in Munich (KoCo-Impf): Risk Factors and Determinants of Immune Response in Healthcare Workers [Viruses] - Incidence and Determinants of Symptomatic and Asymptomatic SARS-CoV-2 Breakthrough Infections After Booster Dose in a Large European Multicentric Cohort of Health Workers-ORCHESTRA Project [Journal of Epidemiology and Global Health] - Multimorbidity and Serological Response to SARS-CoV-2 Nine Months after 1st Vaccine Dose: European Cohort of Healthcare Workers-ORCHESTRA Project [Vaccines] - Determinants of Anti-S Immune Response at 12 Months after SARS-CoV-2 Vaccination in a Multicentric European Cohort of Healthcare Workers-ORCHESTRA Project [Vaccines]