Cohort information

GERMANY				WP2
Organization		LEOSS
Name of cohort		Lean European Open Survey on SARS-CoV-2 infected patients (LEOSS)
Referring partner		UHC
Cohort Information	Country(-ies), cities, regions or centers involved	136 active sites (from different countrys, such as Germany, Turkey, Belgium, Switzerland, Latvia, England, Spain, Austria, Bosnia and Herzegovina, and Italy)
	Time of data collection	03/2020	Ongoing
	Enrolment	Active
	Study setting	Multi-centers
Population	Age	Children,Adolescents,Adults,Elderly
	Type	Retrospective
	Total number of patients	13290
	Site of enrolment (WP2)	Outpatient,Inpatient,ICU
Data collection	Clinical data	True
	Serological data	True
	Genetic data	False
	Sample collection	False
	Sample collected	Whole blood	NA
		PBMC	NA
		Dry-spot blood	NA
		Plasma	NA
		Serum	NA
		Stool	NA
		NP swabs	NA
		Other	NA
Description	LEOSS represents an European, non-interventional cohort study with a multi-centric character (with 136 actively involved sites, predominantly in Germany), as well as a trans-sectoral character (including university sites, non-university sites, medical practices, as well as stationary and ambulatory patients). This study uses an open, anonymous and retrospective documentation approach and has been able to build a relevant and uniform clinical data set. In this context, socio-demographic and clinical data as well as laboratory parameters on all phases of the infection have been collected in LEOSS, focusing on hospitalized and ambulatory patients (acute disease). This allows analysing and identifying independent predictors of outcome in SARS-CoV-2-infected patients, as well as the changes of those predictors during the pandemic waves. Furthermore, the LEOSS eCRF has been extended regularly involving acquired knowledge regarding the dynamics of the pandemic (e.g. virus mutations of SARS-CoV-2, vaccinations, and treatments) and addressing more sub-cohorts by special modules (e.g. ethics and palliative care), which have been designed in collaboration with the respective medical societies. Furthermore, the LEOSS eCRF has been extended regularly involving acquired knowledge regarding the dynamics of the pandemic (e.g. virus mutations of SARS-CoV-2, vaccinations, and treatments) and addressing more sub-cohorts by special modules (e.g. ethics and palliative care), which have been designed in collaboration with the respective medical societies.