| ITALY | WP5 | |||
| Organization | University of Brescia - ASST Spedali Civili | |||
| Name of cohort | ASST Spedali Civili | |||
| Referring partner | UNIBO | |||
| Cohort Information | Country(-ies), cities, regions or centers involved | University Hospital ASST Spedali Civili network, which includes three facilities (Brescia, Montichiari and Gardone Val Trompia) and territorial services located in the county of Brescia. | ||
| Time of data collection | 04/2020 | 10/2022 | ||
| Enrolment | Active | |||
| Study setting | Multi-centers | |||
| Population | Age | Adults,Elderly | ||
| Type | Both | |||
| Total number of patients | 8903 | |||
| Data collection | Clinical data | False | ||
| Serological data | True | |||
| Genetic data | True | |||
| Sample collection | True | |||
| Sample collected | Whole blood | Yes | ||
| PBMC | No | |||
| Dry-spot blood | No | |||
| Plasma | No | |||
| Serum | No | |||
| Stool | No | |||
| NP swabs | Yes | |||
| Other | None | |||
| Description | Register of symptoms onset or close contact with a confirmed COVID case occurred among our cohort before vaccination, with details on symptoms experienced, contact set, PPE used and kind of source. Molecular swabs performed with information about age, gender, job title, vaccination status, type of vaccine. Information on clinical course (symptoms experienced and time for recovering) in case of post-vaccine infection identified via molecular swab. Serological test results with information about gender, age, job title, vaccination status and type of vaccine administered. Post-vaccine anti-N seroconversions. Post-vaccine anti-S and anti-N seroreversions. Interferon Gamma Release Assay results (6 vaccinated workers not showing anti-SARS-CoV-2-Spike antibodies). | |||
| Publications |
- Serological response after SARS-CoV2 vaccination in healthcare workers: a multicenter study [La Medicina del Lavoro] - Determinants of Anti-S Immune Response at 9 Months after COVID-19 Vaccination in a Multicentric European Cohort of Healthcare Workers-ORCHESTRA Project [Viruses] - Temporal trends of COVID-19 antibodies in vaccinated healthcare workers undergoing repeated serological sampling: An individual-level analysis within 13 months in the ORCHESTRA cohort [Frontiers in Immunology] - The Effect of the Immunization Schedule and Antibody Levels (Anti-S) on the Risk of SARS-CoV-2 Infection in a Large Cohort of Healthcare Workers in Northern Italy [Vaccines] | |||