Cohort information

ITALY				WP4
Organization		University of Bologna
Name of cohort		CONTRAST (SOT Lung)
Referring partner		UNIBO
Cohort Information	Country(-ies), cities, regions or centers involved	Bologna, Italy
	Time of data collection	03/2021	Ongoing
	Enrolment	Inactive
	Study setting	Single center
Population	Age	Adults,Elderly
	Type	Both
	Total number of patients	53
	Type of frailty (WP4)	SOT_lung
Data collection	Clinical data	True
	Serological data	True
	Genetic data	False
	Sample collection	True
	Sample collected	Whole blood	Yes
		PBMC	No
		Dry-spot blood	No
		Plasma	No
		Serum	Yes
		Stool	No
		NP swabs	Yes
		Other	Peripheral blood mononuclear cells
Description	UNIBO will participate in the recruitment of the following SARS-CoV-2 and non-SARS-CoV-2 fragile populations: HIV positive, solid organ transplant recipients, hematopoietic stem cell transplant recipients and solid cancer. CONTRAST is an observational cohort study, with a retrospective phase (2015-2020) and a prospective phase (2021-2025) with a minimum follow-up expected for each patient of 1 year. Patients will be studied longitudinally to define the ""net state of immunosuppression"" of each patient to be correlated with the prevalence of SARS-CoV-2 infection, the course of infection in the short, medium and long term, and the immune response to following a SARS-CoV-2 infection or vaccine.
Publications	- Preliminary Evidence on Pulmonary Function after Asymptomatic and Mild COVID-19 in Children [Children] - Risk factors for community and intra-household transmission of SARS-Cov-2: a modelling study in the French national population-based EpiCov cohort [American Journal of Epidemiology] - Association of Patients’ Epidemiological Characteristics and Comorbidities with Severity and Related Mortality Risk of SARS-CoV-2 Infection: Results of an Umbrella Systematic Review and Meta-Analysis [Biomedicines]