Cohort information

ITALY				WP4
Organization		University of Bologna
Name of cohort		CONTRAST (SOT Liver)
Referring partner		UNIBO
Cohort Information	Country(-ies), cities, regions or centers involved	Bologna, Italy
	Time of data collection	03/2021	Ongoing
	Enrolment	Inactive
	Study setting	Single center
Population	Age	Adults,Elderly
	Type	Both
	Total number of patients	274
	Type of frailty (WP4)	SOT_liver
Data collection	Clinical data	True
	Serological data	True
	Genetic data	False
	Sample collection	True
	Sample collected	Whole blood	Yes
		PBMC	No
		Dry-spot blood	No
		Plasma	No
		Serum	Yes
		Stool	No
		NP swabs	Yes
		Other	Peripheral blood mononuclear cells
Description	UNIBO will participate in the recruitment of the following SARS-CoV-2 and non-SARS-CoV-2 fragile populations: HIV positive, solid organ transplant recipients, hematopoietic stem cell transplant recipients and solid cancer. CONTRAST is an observational cohort study, with a retrospective phase (2015-2020) and a prospective phase (2021-2025) with a minimum follow-up expected for each patient of 1 year. Patients will be studied longitudinally to define the ""net state of immunosuppression"" of each patient to be correlated with the prevalence of SARS-CoV-2 infection, the course of infection in the short, medium and long term, and the immune response to following a SARS-CoV-2 infection or vaccine.
Publications	- Evaluation of the Kinetics of Antibody Response to COVID-19 Vaccine in Solid Organ Transplant Recipients: The Prospective Multicenter ORCHESTRA Cohort [Microorganisms] - Relationship between immune response to SARS-CoV2 vaccines and development of breakthrough infection in solid organ transplant recipients: the CONTRAST cohort [Clinical Infectious Diseases] - Using machine learning to predict antibody response to SARS-CoV-2 vaccination in Solid Organ Transplant Recipients. The multicentre ORCHESTRA cohort [Clinical Microbiology and Infection]