Cohort information

ITALY				WP4
Organization		PENTA
Name of cohort		CASE - COVID-19 Household cohort
Referring partner		PENTA
Cohort Information	Country(-ies), cities, regions or centers involved	Italy
	Time of data collection	03/2020	Ongoing
	Enrolment	Active
	Study setting	Multi-centers
Population	Age	Children,Adolescents,Adults
	Type	Prospective
	Total number of patients	1600
	Type of frailty (WP4)	Pediatric,immunocompromised kids
Data collection	Clinical data	True
	Serological data	True
	Genetic data	False
	Sample collection	True
	Sample collected	Whole blood	Yes
		PBMC	No
		Dry-spot blood	No
		Plasma	No
		Serum	No
		Stool	No
		NP swabs	No
		Other	None
Description	Prospective cohort of family clusters of COVID-19. Families are enrolled 8-12 weeks after COVID-19 and then are followe up every 6 months for a clinical and serological evaluation after infection e/o vaccination. Inclusion criteria: we enroll families with at least one member of paediatric age (0-18 years old), with history of confirmed SARS-CoV-2 among one or more household members.
Publications	- Clinical efficacy of different monoclonal antibody regimens among non-hospitalised patients with mild to moderate COVID-19at high risk for disease progression: a prospective cohort study [European Journal of Clinical Microbiology & Infectious Diseases] - From first to second wave: follow-up of the prospective COVID-19 cohort (KoCo19) in Munich (Germany) [BMC Infectious Diseases] - Seroepidemiology and model-based prediction of SARS-CoV-2 in Ethiopia: longitudinal cohort study among front-line hospital workers and communities [The Lancet Global Health] - The incidence and risk factors of selected drug prescriptions and outpatient care after SARS-CoV-2 infection in low-risk subjects: a multicenter population-based cohort study [Frontiers in Public Health] - Clinical Impact of Monoclonal Antibodies in the Treatment of High-Risk Patients with SARS-CoV-2 Breakthrough Infections: The ORCHESTRA Prospective Cohort Study [Biomedicines] - Studying temporal titre evolution of commercial SARS-CoV-2 assays reveals significant shortcomings of using BAU standardization for comparison [Virology Journal] - The impact of SARS-CoV-2 on healthcare workers of a large University Hospital in the Veneto Region: risk of infection and clinical presentation in relation to different pandemic phases and some relevant determinants [Frontiers in Public Health]