Cohort information

ITALY				WP4
Organization		PENTA
Name of cohort		CASE - COVID-19 Household cohort
Referring partner		PENTA
Cohort Information	Country(-ies), cities, regions or centers involved	Italy
	Time of data collection	03/2020	Ongoing
	Enrolment	Active
	Study setting	Multi-centers
Population	Age	Children,Adolescents,Adults
	Type	Prospective
	Total number of patients	1600
	Type of frailty (WP4)	Pediatric,immunocompromised kids
Data collection	Clinical data	True
	Serological data	True
	Genetic data	False
	Sample collection	True
	Sample collected	Whole blood	Yes
		PBMC	No
		Dry-spot blood	No
		Plasma	No
		Serum	No
		Stool	No
		NP swabs	No
		Other	None
Description	Prospective cohort of family clusters of COVID-19. Families are enrolled 8-12 weeks after COVID-19 and then are followe up every 6 months for a clinical and serological evaluation after infection e/o vaccination. Inclusion criteria: we enroll families with at least one member of paediatric age (0-18 years old), with history of confirmed SARS-CoV-2 among one or more household members.
Publications	- Left ventricular longitudinal strain alterations in asymptomatic or mildly symptomatic paediatric patients with SARS-CoV-2 infection [European Heart Journal - Cardiovascular Imaging] - Mild SARS-CoV-2 Infections and Neutralizing Antibody Titers [Pediatrics] - Protective SARS-CoV-2 Antibody Response in Children With Inflammatory Bowel Disease [Frontiers in Pediatrics] - Preliminary Evidence on Pulmonary Function after Asymptomatic and Mild COVID-19 in Children [Children] - Long-term Immune Response to SARS-CoV-2 Infection Among Children and Adults After Mild Infection [JAMA Network Open] - Perceived Psychological Impact on Children and Parents of Experiencing COVID-19 Infection in One or More Family Members [Children] - Stronger and durable SARS-CoV-2 immune response to mRNA vaccines in 5–11 years old children with prior COVID-19 [Vaccines]