| Description |
LEOSS represents an European, non-interventional cohort study with a multi-centric character (with 136 actively involved sites, predominantly in Germany), as well as a trans-sectoral character (including university sites, non-university sites, medical practices, as well as stationary and ambulatory patients). This study uses an open, anonymous and retrospective documentation approach and has been able to build a relevant and uniform clinical data set. In this context, socio-demographic and clinical data as well as laboratory parameters on all phases of the infection have been collected in LEOSS, focusing on hospitalized and ambulatory patients. This allows analysing and identifying independent predictors of outcome in SARS-CoV-2-infected patients, as well as the changes of those predictors during the pandemic waves.
Furthermore, the LEOSS eCRF has been extended regularly involving acquired knowledge regarding the dynamics of the pandemic (e.g. virus mutations of SARS-CoV-2, vaccinations, and treatments) and addressing more sub-cohorts by special modules (e.g. ethics and palliative care), which have been designed in collaboration with the respective medical societies. |