| Description |
In 100 out of 755 randomly selected constituencies, 3007 Munich households are identified via random route and offered enrollment into the study. In the first round of the study all household members are asked to complete a baseline questionnaire, subjects ≥14 years of age are asked to provide a venous blood sample of ≤3 ml and subjects <14 years are asked to provide a finger prick blood sample for the determination of SARS-CoV-2 antibody status. The residual plasma and the blood pellet are preserved for later genetic and molecular biological investigations. During the first round, each household member is asked to keep a diary of daily symptoms, whereabouts and contacts via WebApp. After the first round, subjects are asked to keep the diary only on days they are experiencing symptoms. If symptoms suggestive for COVID-19 are reported, family members, including children <14 years, are offered a pharyngeal swab taken at the Division of Infectious Diseases and Tropical Medicine, LMU University Hospital Munich, for molecular testing for SARS-CoV-2. In case of severe symptoms, participants will be transferred to a Munich hospital. From the second round onwards, subjects ≥14 years are sent a test kit for self use finger prick blood sampling. Subjects <14 years and subjects struggeling with taking their blood themselves can come to the Division of Infectious Diseases and Tropical Medicine, LMU University Hospital Munich, to have their blood drawn. Each household member is asked to complete one questionnaire per round. |